In certain cases, withdrawal may last for several months. This is called post-acute withdrawal syndrome PAWS. Individuals facing PAWS experience anxiety, depression, and insomnia. Acute withdrawal from benzodiazepine drugs can become very dangerous, to the extent that professional treatment is necessary medical detox.
Certain individuals may experience withdrawal so severe that their life is in jeopardy. In these instances, withdrawal may cause seizures or delirium tremens. Benzodiazepine overdose is another huge risk associated with the abuse of these drugs.
According to the CDC, from to , two of the top 10 drugs responsible for overdose deaths were benzodiazepines. These were alprazolam Xanax and diazepam Valium. As a central nervous system CNS depressants, benzodiazepines have the capacity to slow vital life support systems to deadly levels. Benzodiazepines are frequently abused with other drugs, commonly with alcohol and opioids, both of which are also central nervous system depressants. This combination makes benzodiazepines even more dangerous and deadly.
Signs of overdose include blue fingernails, double vision, impaired coordination, slurred speech, and slowed or stopped breathing, among others. An overdose is a medical emergency. If an overdose is suspected, contact emergency medical support services immediately. No matter what drugs you or someone you care about is abusing on this list of benzodiazepines, addiction is serious.
Treatment often requires a medically-supervised detox program prior to drug rehabilitation. How long does Klonopin stay in your system after the effects wear off? As a long-acting benzo, Klonopin can build up in the bloodstream and take much longer to leave the body. Klonopin can stay in your system between five to 14 days, depending on your age, metabolic health, and tolerance for the drug. The half-life, or elimination time of Klonopin, can vary significantly from one individual to another.
The liver is the main organ responsible for the metabolization, although some clonazepam is excreted in the urine. When the body metabolizes Klonopin, it is broken down into metabolites.
The primary active metabolite is 7-amioclozaepam, and can also be detected during drug testing to determine Klonopin use. This metabolite may remain detectable even at Klonopin has been eliminated from the body. We can help you overcome addiction and get your life back. Generally speaking, the younger someone is, the more quickly they will process Klonopin. This may be due to having a faster metabolism and overall better health than older people.
However, depending on the overall health of an individual, age may not matter as much as other factors. When discontinuing therapy abruptly, a benzodiazepine with a longer half-life may be advantageous; however, when pharmacotherapy is discontinued gradually, the importance of half-life is diminished.
Studies of the pharmacodynamics of drug-receptor interactions suggest new approaches to minimizing the adverse effects of discontinuing benzodiazepine therapy.
Preliminary data relating plasma alprazolam concentrations to anxiolytic and adverse effects are presented. Abstract Alprazolam, adinazolam, and clonazepam share the typical pharmacological effects of benzodiazepines yet are diverse in their pharmacokinetic properties.
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